inhibitors for the treatment of erectile dysfunction

Seven years of PDE-5 inhibitors for the treatment of erectile dysfunction
Sildenafil revolutionized its market entry in 1998, the treatment of
erectile dysfunction. It is still the best selling product in its drug
class. Its unique history and location make the impressive data for
the drug sildenafil, physicians and scientists exciting. In addition,
the substance stimulates further investigations on - even in
therapeutic areas outside of erectile dysfunction pills.

Viagra ® by doctors and researchers around the world were motivated to
want to understand the reasons behind sexual dysfunction and better
treatment options to improve further. Seven years after its
introduction, the most famous place among the PDE-5 inhibitors is
widely accepted by primary care physicians and urologists.

The positive practical experience with sildenafil treatment are
supported by results from more than 130 clinical trials. National and
international studies at more than 43,000 patients to document the
efficacy and tolerability. Surveys of users have also shown that
treatment with Viagra pills, the male fulfilled expectations. Even the
women were shown in order to ask-satisfied with the treatment results
of their partners.

For not only benefit the victims themselves physically and mentally
from the treatment: A recent study by Raymond Rosen shows, through a
successful ED therapy also improved partnership, family life and
quality of life significantly.

More astonishing is that - are erectile dysfunction undertreated and
underdiagnosed still - despite the large presence of the topic
sexuality in everyday life. As before, there are men involved in the
high barriers to address the issue openly. In Germany alone, experts
estimate five million men with erectile dysfunction, but of which only
about one in four speaks to his doctor. Erection problems are
perceived differently by each man. But even mild or occasional
impairment of erectile function may trigger a high subjective
distress. This is often accompanied by uncertainty and fear of failure
which discourage the individuals to whom to entrust themselves to
their partner or doctor.

Pfizer assumes its responsibilities as a pioneer in the field of
sexual health and is particularly active in educational work. This
takes the initiative, "Body & Soul man" on the wishes and needs for an
open and positive approach. The aim is to encourage such men to ask
for a solution to their problem. At the same doctors to help is
offered for patient education in order to more easily get into the
sensitive subject of sexuality can. Erectile dysfunction should be
taken so forth out of the taboo zone to open up people the opportunity
to get a sex life and an improved quality of life.

erectile dysfunction after prostate cancer surgery

Study: Erectile dysfunction after prostate cancer surgery
After a radical prostatectomy complain up to 50 percent of men over the long-term erectile dysfunction, even if the nerves spared during surgery. Medications such as sildenafil or prostaglandin E1 can help those affected. A community study wants to clarify which drug is more effective. Also, the University Hospital of Bonn, is involved.

Also, an erection is ultimately question of training. After a prostate operation, one has but mostly in the first weeks of other problems. "The long break can cause the penis is no longer sufficiently stiffened," said Professor Dr. Stefan C. Müller, urologist at the University of Bonn. "If you break your arm, it is not immediately fully operational as soon as the plaster coming off."

Schlafft broken arm when the musculature, it is after a prostate operation in every second man just the other way around: the smooth muscle in the corpora cavernosa relaxes no longer sufficient. This allows the penile arteries are no longer pump enough blood into the corpora cavernosa: The penis is flaccid.

During sexual arousal usually certain neurotransmitters ensure that the erectile muscle slack: The penis fills with blood and becomes erect. When erectile dysfunction this signaling pathway is disrupted. Medications such as sildenafil or prostaglandin E1 act as a sort of signal amplifier. They also seem to prevent the erection mechanism permanently "attaches rust".

Undergo in their comparative study, the urologists from Bonn both drugs in the truest sense of the word "endurance test". The volunteers receive several times a week either sildenafil or prostaglandin E1. The treatment begins within a few days after prostate surgery, and extends over 36 weeks. During the study, and the medical record at the end of the erectile function of their patients by questionnaire. Professor Müller: "We hope that such important insights for better rehabilitation of prostate patients."

Professor Dr. Dr. h.c. Stefan C. Mueller
Department of Urology, University Hospital Bonn
E-mail: @ stefan.mueller ukb.uni-bonn.de

symptoms and erectile dysfunction

Erectile dysfunction: an indicator of diabetes, hypertension, hyperlipidemia, and depression
A Erectile dysfunction (ED) is often associated with other diseases. In May 2004 resulted in the Congress of the American Urological Association (AUA) in San Francisco published a retrospective comparison of health data among men with and without ED: 68 percent of surveyed ED patients had at least one other disease: diabetes mellitus (20.2% ) (2), hypertension (41.6 (2)%), hyperlipidemia or depression. A diagnosis of ED is therefore suitable as a predictor of serious underlying disease.

The prevalence of common diseases such as diabetes mellitus and hypertension compared to men with ED and without ED were each, in two cohort studies (1), (2) the data of up to 28 retrospectively analyzed millions of Americans.

ED - high blood pressure marker

Both the organic and the ED-related hypertension in general is based on a narrowing of blood vessels. Men with ED therefore more likely to suffer from high blood pressure than men without ED. This association between ED and hypertension was first detected now with empirical evidence (1). The prevalence of hypertension was compared for a total of 285 436 ED patients and retrospectively 1.58423 million men without ED.

In the group of men with ED, 41.2% suffered from high blood pressure. By contrast, during the non-ED group are found only in 19.2% of hypertension. In the diagnosis of ED should also always take place to monitor blood pressure. While the ED is most clearly recognized by the patients, hypertension, however, often not suffering, so that it does not perceive the victims. Thus, the ED as a marker for hypertension contribute to discover this dangerous vascular disease at an early stage.

ED and other diseases

If an ED caused by pathological vascular changes, individuals often suffer from other serious health problems. In addition to the prevalence of hypertension, therefore, hyperlipidemia, diabetes mellitus and depression in men with ED was calculated (2). A total of 42.4% of all men with ED and hyperlipidemia 20.2% had diabetes mellitus. From depression were also 11.1% of all men ill, in which an ED was diagnosed.

The frequency of the studied comorbidities generally increases with increasing age.While in the group of 18 - to 24-year-olds showed only 4.5% for hypertension, the proportion increased in men over 86 years to 68.4%. For hyperlipidemia, the prevalence increased from 3.9% at 18 - to 24-year-olds to 52.3% at 56 - to 65-year-olds. Also shows an increasing prevalence of diabetes mellitus with 2.8% in the age group 18 to 24 years to 28.7% among 66 - to 75-year-old patient. Only depression occurred more frequently with increasing age does not. Depending on the age range 5.8 to 15% of all ED patients were depressed.
ED as a predictor

Only 32% of all enrolled in the study ED patients had none of the four diseases studied. ED must therefore be taken seriously as a health warning. Physicians should make greater use of ED as an early warning of associated diseases, to treat such serious underlying diseases at an early stage. A comprehensive and differential diagnosis of ED should always take into account also additional diseases. Moreover, for the history in a general patient population to basically ask the question of the erectile function as a Sensitive parameters for vascular disease.

1) Sun, P. & swindler, R.: Comparison of Hypertension Prevalence Rates Between Men with Erectile Dysfunction and Men Without Erectile Dysfunction: Abstract: AUA, San Francisco, 7th-12th May 2004.
2) Sun, P., Seftel, A.D. And swindlers, R.: The Prevalence of Four Concurrent Conditions Diagnosed Among Male Health Plan Members with Erectile Dysfunction: Abstract: 7th-12th May 2004.

sexual health practitioner

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